OUR MISSION
BlueSky Immunotherapies GmbH (Ltd.) is a clinical-stage biotech company. The company’s business is based on its own proprietary, novel technology platform for interferon-inducing viral vectors (delNS). Interferons have immunostimulatory and antiviral properties. BlueSky uses these delNS- mediated properties for therapies against cancer and viral infectious diseases.
TECHNOLOGY
The high level of interferon induced by the delNS vector activates immunological defence reactions against cancer. It also stimulates the production of antiviral molecules:
Immunostimulation / Immunomodulation
– NK –
activates Natural Killer Cells
– CTL –
activates Cytotoxic T-Cells
– DC –
activates Dendritic Cells
– Treg –
inhibits Immunosuppressive Regulatory T-Cells
– ΜΦ –
activates Macrophage
Antiviral molecules / Inhibition of viral replication
– ISG15 –
Interferon stimulated gene 15
– OAS –
Oligoadenylate synthetase
– PKR –
Protein Kinase R
– Mx –
Interferon-induced GTP binding protein
REFERENCES / PUBLICATIONS delNS
The original paper Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems (Virology 252,324) has accumulated 1248 citations in peer – reviewed journals (Google Scholar, December 2021).
The immunogenic properties and safety of delNS-based viruses have been widely published in top journals. A selection of corresponding papers is provided below:
- PLoS ONE 16(11): e0260155 / Elimination of equine sarcoids (10494 downloads)
- Scientific Reports 11, 22164 /Antiviral properties through interference (11673 downloads)
- J Virol 74,6203 / activation of PKR (10707 downloads)
- J Virol 76,1617 / induction of apoptosis (11430 downloads)
- J Infect Dis 201,354 / B-cell mediated local and systemic response (11359 downloads)
- Med Microbiol Immunol 199,93 / activation of NK cells (11358 downloads)
- Vaccine 37,3722 / B-cell mediated response (10884 downloads)
- PLoS One 10(9) e0138722 / T-cell mediated response against E6E7 (12200 downloads)
- Nature 424,324 / activation dentritic cells and induction IFN (11138 downloads)